Multi-gram scale synthesis of FR180204

J Org Chem. 2009 Nov 20;74(22):8870-3. doi: 10.1021/jo901835m.

Abstract

A concise synthesis of the ERK inhibitor FR180204 has been developed. The synthesis consists of six operationally simple steps and can be utilized to make multi-gram quantities of FR180204.

MeSH terms

  • Molecular Structure
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyridazines / chemical synthesis*
  • Pyridazines / chemistry
  • Stereoisomerism

Substances

  • FR 180204
  • Pyrazoles
  • Pyridazines