Hormonal regulation of microRNA biogenesis

Mol Cell. 2009 Oct 23;36(2):172-3. doi: 10.1016/j.molcel.2009.10.006.

Abstract

In this issue of Molecular Cell, Yamagata et al. (2009) provide insight into the complex posttranscriptional regulation of miRNA biogenesis by showing that the processing of a subset of miRNAs is inhibited by the estrogen receptor.

MeSH terms

  • 3' Untranslated Regions / metabolism
  • Animals
  • Estrogen Receptor alpha / metabolism*
  • Estrogens / pharmacology*
  • Humans
  • Mice
  • MicroRNAs / biosynthesis*
  • MicroRNAs / genetics
  • Models, Genetic
  • Ribonuclease III / metabolism
  • Vascular Endothelial Growth Factor A / genetics

Substances

  • 3' Untranslated Regions
  • Estrogen Receptor alpha
  • Estrogens
  • MicroRNAs
  • Vascular Endothelial Growth Factor A
  • Drosha protein, mouse
  • Ribonuclease III