Synthesis and Mössbauer characterization of octahedral iron(II) carbonyl complexes FeI2(CO)3L and FeI2(CO)2L2: developing models of the [Fe]-H(2)ase active site

Inorg Chem. 2009 Dec 7;48(23):11283-9. doi: 10.1021/ic9017882.

Abstract

A series of mono- and disubstituted complexes, FeI(2)(CO)(x)L(4-x), x = 2 or 3, is conveniently accessed from simple mixing of N-heterocyclic carbenes, phosphines, and aromatic amines with FeI(2)(CO)(4), first reported by Hieber in 1928. The highly light sensitive complexes yield to crystallization and X-ray diffraction studies for six complexes showing them to be rudimentary structural models of the monoiron hydrogenase, [Fe]-H(2)ase or Hmd, active site in native (Fe(II)(CO)(2)) or CO-inhibited (Fe(II)(CO)(3)) states. Diatomic ligand (nu(CO)) vibrational and Mossbauer spectroscopies are related to those reported for the Hmd active site. The importance of a serial approach for relating such parameters in model compounds to low spin Fe(II) in the diverse ligation of enzyme active sites is stressed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Carbon Monoxide / chemistry*
  • Catalytic Domain
  • Crystallography, X-Ray
  • Ferrous Compounds / chemical synthesis*
  • Ferrous Compounds / chemistry
  • Hydrogenase / chemistry*
  • Hydrogenase / metabolism
  • Iron-Sulfur Proteins / chemistry*
  • Iron-Sulfur Proteins / metabolism
  • Ligands
  • Models, Molecular
  • Molecular Conformation
  • Spectroscopy, Mossbauer

Substances

  • Ferrous Compounds
  • Iron-Sulfur Proteins
  • Ligands
  • Carbon Monoxide
  • iron hydrogenase
  • Hydrogenase