JAK2 gets histone H3 rolling

Cancer Cell. 2009 Nov 6;16(5):365-6. doi: 10.1016/j.ccr.2009.10.009.

Abstract

Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 releases the transcriptional repressor HP1alpha from chromatin, resulting in gene transcription.

Publication types

  • Review

MeSH terms

  • Cell Line, Tumor
  • Chromobox Protein Homolog 5
  • Histones / metabolism*
  • Humans
  • Janus Kinase 2 / antagonists & inhibitors
  • Janus Kinase 2 / metabolism*
  • Phosphorylation

Substances

  • CBX5 protein, human
  • Histones
  • Chromobox Protein Homolog 5
  • JAK2 protein, human
  • Janus Kinase 2