Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis

Arch Pharm Res. 2009 Oct;32(10):1409-15. doi: 10.1007/s12272-009-2010-7. Epub 2009 Nov 8.

Abstract

Thirteen lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1'-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC(50) values; 13, 12, 11, and 10 microM, respectively) and HepG2 cell lines (IC(50) values; 16, 11, 12, and 11 microM, respectively).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Molecular Structure
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Saururaceae / chemistry*
  • Topoisomerase I Inhibitors*
  • Topoisomerase II Inhibitors*

Substances

  • Enzyme Inhibitors
  • Lignans
  • Plant Extracts
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors