Abstract
We report the case of a 35 year patient from Nigeria who presented with fever and splenomegaly. The initial diagnosis was Salmonellosis. However, relapsing symptoms lead to a re-evaluation and ultimately a diagnosis of Multicentric Castleman's Disease (MCD). There is no gold standard treatment but our patient responded to Rituximab and Highly active anti-retroviral therapy. MCD is a rare, aggressive disease that should be considered in a HIV positive patient presenting with fever and significant lymphadenopathy.
MeSH terms
-
Adult
-
Anti-Infective Agents / therapeutic use
-
Antibodies, Monoclonal / therapeutic use*
-
Antibodies, Monoclonal, Murine-Derived
-
Antiretroviral Therapy, Highly Active*
-
Castleman Disease / diagnosis*
-
Castleman Disease / drug therapy
-
Castleman Disease / pathology
-
Castleman Disease / surgery
-
Ciprofloxacin / therapeutic use
-
Herpesvirus 8, Human*
-
Humans
-
Immunologic Factors / therapeutic use*
-
Male
-
Rituximab
-
Splenomegaly
Substances
-
Anti-Infective Agents
-
Antibodies, Monoclonal
-
Antibodies, Monoclonal, Murine-Derived
-
Immunologic Factors
-
Rituximab
-
Ciprofloxacin