Synthesis and evaluation of l-5-(2-[(18)F]fluoroethoxy)tryptophan as a new PET tracer

Ruifen Li; Shih-Chen Wu; Shih-Chen Wang; Zhe Fu; Yonghong Dang; Li Huo

doi:10.1016/j.apradiso.2009.10.007

Synthesis and evaluation of l-5-(2-[(18)F]fluoroethoxy)tryptophan as a new PET tracer

Appl Radiat Isot. 2010 Feb;68(2):303-8. doi: 10.1016/j.apradiso.2009.10.007. Epub 2009 Oct 14.

Authors

Ruifen Li¹, Shih-Chen Wu, Shih-Chen Wang, Zhe Fu, Yonghong Dang, Li Huo

Affiliation

¹ Department of Nuclear Medicine, Perking Union Medical College Hospital, Chinese Academy of Medical Sciences & Perking Union Medical College, Beijing 100730, China. [email protected]

PMID: 19906535
DOI: 10.1016/j.apradiso.2009.10.007

Abstract

A convenient remote controlled synthesis of a new tryptophan analog, l-5-(2-[(18)F] fluoroethoxy)-tryptophan (5-(18)FEHTP) was described. The radiochemical yield within 65min was about 12-16% without decay correction, the radiochemical purity was over 98%, and 5-(18)FEHTP dissolved in saline was stable over 6h at room temperature. The biodistribution of 5-(18)FEHTP in mice and the high uptake of 5-(18)FEHTP in tumor demonstrated that it is very likely a new PET tracer for tumor imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / metabolism
Image Enhancement / methods
Inflammation / diagnostic imaging*
Inflammation / metabolism
Isotope Labeling / methods
Metabolic Clearance Rate
Mice
Organ Specificity
Positron-Emission Tomography / methods*
Radiopharmaceuticals / chemical synthesis
Radiopharmaceuticals / pharmacokinetics*
Tissue Distribution
Tryptophan / analogs & derivatives*
Tryptophan / chemistry
Tryptophan / pharmacokinetics

Substances

5-(2-fluoroethoxy)tryptophan
Radiopharmaceuticals
Tryptophan