Abstract
Water and ethyl diazoacetate were found to be matched components for generating highly reactive nucleophilic oxonium ylide in the presence of a dirhodium acetate catalyst. Simultaneous trapping of the oxonium ylide intermediate with aryl imines gave beta-aryl isoserine derivatives with high diastereoselectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Crystallography, X-Ray
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Diazonium Compounds / chemistry*
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Imines / chemistry*
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemistry*
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Rhodium / chemistry*
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Serine / analogs & derivatives*
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Serine / chemical synthesis
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Serine / chemistry
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Stereoisomerism
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Water / chemistry*
Substances
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Diazonium Compounds
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Imines
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Organometallic Compounds
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Water
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Serine
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isoserine
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Rhodium
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diazoacetic ester