Fabrication of nano scaled protein monolayer consisting of cytochrome c on self-assembled 11-MUA layer for bioelectronic device

J Nanosci Nanotechnol. 2009 Dec;9(12):7136-40. doi: 10.1166/jnn.2009.1663.

Abstract

The biomolecular/organic hetero-structure films (cytochrome c/11-mercapto-undecanoic acid) on gold substrates were controlled and fabricated with molecular level for developing valuable molecular electronic devices. Cytochrome c is a metalloprotein having redox property, which can be directly applicable to biomemory device as a active element. For efficient immobilization of the protein on the gold substrate, 11-mercapto-undecanoic acid (11-MUA) was used as a linker material between protein and inorganic substrate. The proposed nano scaled biomolecular/organic hetero-structure layer (cytochrome c/11-MUA) on gold surface was investigated by using surface plasmon resonance technique. The molecular morphology of the fabricated protein layer was confirmed by scanning tunneling microscopy. Electrochemical properties of fabricated biomolecular/organic hetero layer were verified using cyclic voltammetry. Their redox properties was sustained over 1000 cycles of cyclic voltametry. It proved that the fabricated film was a suitable platform for the bioelectronic device application.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Coated Materials, Biocompatible / chemistry
  • Crystallization / methods*
  • Cytochromes c / chemistry*
  • Electronics / instrumentation*
  • Equipment Design
  • Equipment Failure Analysis
  • Fatty Acids / chemistry*
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Nanotechnology / instrumentation
  • Particle Size
  • Protein Binding
  • Sulfhydryl Compounds / chemistry*
  • Surface Plasmon Resonance / instrumentation*

Substances

  • 11-mercaptoundecanoic acid
  • Coated Materials, Biocompatible
  • Fatty Acids
  • Sulfhydryl Compounds
  • Cytochromes c