Abstract
The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2-7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Chromosomal Proteins, Non-Histone / metabolism
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DNA / metabolism*
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DNA Helicases / metabolism
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DNA Replication*
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / metabolism
Substances
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Chromosomal Proteins, Non-Histone
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Saccharomyces cerevisiae Proteins
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DNA
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DNA Helicases