Abstract
When 1,1-dimethylhydrazine and N-aminopiperidine were deliberately exposed to air substantial amounts of the corresponding carcinogenic nitrosamines were formed. Unoxidized samples of 1,1-dimethylhydrazine were not mutagenic while oxidized samples (which contained much higher levels of nitrosamines) were mutagenic. Both unoxidized and oxidized samples of N-aminopiperidine were mutagenic.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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1,2-Dimethylhydrazine
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Animals
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Biotransformation
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Chromatography, Gas
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Cricetinae
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Dimethylhydrazines / chemistry*
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Dimethylhydrazines / pharmacology
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Hydrazines / chemistry*
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Male
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Mesocricetus
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Microsomes, Liver / metabolism
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Mutagenicity Tests
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Mutagens / chemistry*
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Nitrosamines*
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Oxidation-Reduction
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Piperidines / chemistry*
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Piperidines / pharmacology
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Rats
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Rats, Inbred Strains
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Salmonella typhimurium / drug effects
Substances
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Dimethylhydrazines
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Hydrazines
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Mutagens
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Nitrosamines
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Piperidines
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N-aminopiperidine
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1,2-Dimethylhydrazine