Abstract
A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Glycosides / chemical synthesis*
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Glycosides / chemistry
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Glycosides / pharmacology*
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Glycyrrhizic Acid*
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Hepatitis, Alcoholic / drug therapy*
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Hepatocytes / metabolism*
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Hepatocytes / pathology
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Humans
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Models, Biological
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Triterpenes / chemical synthesis*
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Triterpenes / chemistry
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Triterpenes / pharmacology*
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Glycosides
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Triterpenes
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Tumor Necrosis Factor-alpha
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Glycyrrhizic Acid