Change in the proton T(1) of fat and water in mixture

Magn Reson Med. 2010 Feb;63(2):494-501. doi: 10.1002/mrm.22205.

Abstract

This work describes observed changes in the proton T(1) relaxation time of both water and lipid when they are in relatively homogeneous mixtures. Results obtained from vegetable oil-water emulsions, pork kidney and lard mixtures, and excised samples of white and brown adipose tissues are presented to demonstrate this change in T(1) as a function of mixture fat fraction. As an initial proof of concept, a simpler acetone-water experiment was performed to take advantage of complete miscibility between acetone and water and both components' single chemical shift peaks. Single-voxel MR spectroscopy was used to measure the T(1) of predominant methylene spins in fat and the T(1) of water spins in each setup. In the vegetable oil-water emulsions, the T(1) of fat varied by as much as 3-fold when water was the dominant mixture component. The T(1) of pure lard increased by 170 msec (+37%) when it was blended with lean kidney tissue in a 16% fatty mixture. The fat T(1) of lipid-rich white adipose tissue was 312 msec. In contrast, the fat T(1) of leaner brown adipose tissue (fat fraction 53%) was 460 msec. A change in the water T(1) from that of pure water was also observed in the experiments.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Complex Mixtures / chemistry*
  • Emulsions / chemistry
  • Fats / chemistry*
  • Magnetic Resonance Spectroscopy / methods*
  • Protons
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Swine
  • Water / chemistry*

Substances

  • Complex Mixtures
  • Emulsions
  • Fats
  • Protons
  • Water