Abstract
A new coumarin, 7-hydroxy-4,6-dimethoxy-5-methylcoumarin (1), was isolated from the aerial parts of Clematis delavayi var. spinescens together with 17 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of all compounds were evaluated using a zebrafish model.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Angiogenesis Inhibitors / pharmacology
-
Animals
-
Clematis / chemistry*
-
Coumarins / chemistry*
-
Coumarins / pharmacology*
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Phthalazines / pharmacology
-
Pyridines / pharmacology
-
Zebrafish
Substances
-
Angiogenesis Inhibitors
-
Coumarins
-
Phthalazines
-
Pyridines
-
vatalanib
-
coumarin