Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99m

Bioorg Med Chem Lett. 2010 Jan 1;20(1):315-7. doi: 10.1016/j.bmcl.2009.10.104. Epub 2009 Oct 29.

Abstract

Three carbohydrate derivatives, MAG(3)-Gl, MAG(3)-Ga, MAG(3)-NG, were synthesized and radiolabeled in high yields. These substances were injected in health Swiss mice and their biodistribution were evaluated. Among them, (99m)Tc-MAG(3)-Ga displayed higher accumulation in hepatic tissue, due to the presence of specific receptors in the liver for this carbohydrate. Thus, the use of (99m)Tc-MAG(3)-Ga to assess hepatic function can be considered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbohydrates / chemical synthesis
  • Carbohydrates / chemistry*
  • Carbohydrates / pharmacokinetics
  • Glycine / analogs & derivatives
  • Glycine / chemistry
  • Glycine / pharmacokinetics
  • Isotope Labeling
  • Liver / metabolism
  • Mice
  • Technetium Tc 99m Mertiatide / chemistry*
  • Technetium Tc 99m Mertiatide / pharmacokinetics
  • Tissue Distribution

Substances

  • Carbohydrates
  • N-(mercaptoacetyl)glycine
  • Technetium Tc 99m Mertiatide
  • Glycine