Silica sulfuric acid promotes aza-Michael addition reactions under solvent-free condition as a heterogeneous and reusable catalyst

Molecules. 2009 Nov 23;14(11):4779-89. doi: 10.3390/molecules14114779.

Abstract

A highly efficient, inexpensive, recyclable, convenient, and green protocol for chemoselective aza-Michael addition reactions of amines/thiols to alpha,beta-unsaturated compounds using silica sulfuric acid (SSA or SiO(2)-SO(3)H) was developed. This method is simple, convenient and the title compounds are produced in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry
  • Catalysis
  • Molecular Structure
  • Silicon Dioxide / chemistry*
  • Solvents / chemistry*
  • Sulfuric Acids / chemistry*

Substances

  • Alkenes
  • Solvents
  • Sulfuric Acids
  • Silicon Dioxide
  • sulfuric acid