Antimicrobial susceptibility of multidrug-resistant Streptococcus pneumoniae strains with penicillin MICs of 8 to 32 mg/L

Violeta Rodríguez-Cerrato; Matilde Gracia; Gema Del Prado; Lorena Huelves; Plínio Naves; Vicente Ruiz; Carmen Ponte; Francisco Soriano

doi:10.1016/j.diagmicrobio.2009.10.015

Antimicrobial susceptibility of multidrug-resistant Streptococcus pneumoniae strains with penicillin MICs of 8 to 32 mg/L

Diagn Microbiol Infect Dis. 2010 Mar;66(3):336-8. doi: 10.1016/j.diagmicrobio.2009.10.015. Epub 2009 Nov 25.

Authors

Violeta Rodríguez-Cerrato¹, Matilde Gracia, Gema Del Prado, Lorena Huelves, Plínio Naves, Vicente Ruiz, Carmen Ponte, Francisco Soriano

Affiliation

¹ Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz-Capio, 28040 Madrid, Spain. [email protected]

PMID: 19939599
DOI: 10.1016/j.diagmicrobio.2009.10.015

Abstract

The in vitro activity of 22 antibiotics (including novobiocin) and beta-lactam/gentamicin combinations was assessed against 11 multidrug-resistant pneumococcal strains. Among orally administered drugs, only telithromycin, levofloxacin, and linezolid were active against all isolates, but their use is not indicated in pediatrics. Novobiocin could be a potential therapeutic alternative.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Penicillins / pharmacology*
Pneumococcal Infections / microbiology*
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / isolation & purification

Substances

Anti-Bacterial Agents
Penicillins