Abstract
Two new glycosylated macrolactones, apoptolidins E (5) and F (6), were isolated from fermentation of the actinomycete Nocardiopsis sp. and their structures assigned. Lacking the C16 and C20 oxygens of apoptolidin A (1), these macrolides are also the first members of this family to display a 4-O-methyl-l-rhamnose at C9 rather than a 6-deoxy-4-O-methyl-l-glucose.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinobacteria / chemistry*
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Drug Screening Assays, Antitumor
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Glucose / chemistry
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Glycosylation
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Humans
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Molecular Structure
Substances
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Macrolides
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apoptolidin E
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apoptolidin F
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Glucose