Glycodelin-A modulates cytokine production of peripheral blood natural killer cells

Fertil Steril. 2010 Jul;94(2):769-71. doi: 10.1016/j.fertnstert.2009.10.009. Epub 2009 Nov 27.

Abstract

Glycodelin-A increased the secretion of interleukin-6, interleukin-13, and granulocyte-macrophage colony-stimulating factor from natural killer cells in the peripheral blood but does not affect their viability, cell death, and cytotoxicity. These data suggest that glycodelin-A contributes to the cytokine shift in early pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Death / immunology
  • Cell Survival / immunology
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Decidua / cytology
  • Decidua / immunology*
  • Decidua / metabolism
  • Female
  • Glycodelin
  • Glycoproteins / immunology*
  • Glycoproteins / metabolism
  • Glycoproteins / pharmacology
  • Granulocyte-Macrophage Colony-Stimulating Factor / immunology
  • Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
  • Humans
  • In Vitro Techniques
  • Interleukin-13 / immunology
  • Interleukin-13 / metabolism
  • Interleukin-6 / immunology
  • Interleukin-6 / metabolism
  • Killer Cells, Natural / cytology
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology*
  • Pregnancy
  • Pregnancy Proteins / immunology*
  • Pregnancy Proteins / metabolism
  • Pregnancy Proteins / pharmacology
  • Pregnancy Trimester, First / immunology
  • Pregnancy Trimester, First / metabolism
  • Trophoblasts / cytology
  • Trophoblasts / immunology*
  • Trophoblasts / metabolism

Substances

  • Cytokines
  • Glycodelin
  • Glycoproteins
  • IL6 protein, human
  • Interleukin-13
  • Interleukin-6
  • PAEP protein, human
  • Pregnancy Proteins
  • Granulocyte-Macrophage Colony-Stimulating Factor