Abstract
The small GTP-binding protein Arf6 is known to be an important regulator of the actin cytoskeleton and of cell motility associated with metastasis. A recent study identifies yet another role for Arf6 in metastasis - as a regulator of plasma-membrane-derived microvesicle release.
MeSH terms
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ADP-Ribosylation Factor 6
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ADP-Ribosylation Factors / genetics
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ADP-Ribosylation Factors / physiology*
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Animals
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Genes, Lethal
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Humans
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Mice
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Mice, Knockout
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Neoplasm Metastasis / physiopathology*
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Signal Transduction
Substances
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ADP-Ribosylation Factor 6
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ADP-Ribosylation Factors
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ARF6 protein, human
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Arf6 protein, mouse