Recurrent ischemic stroke in a patient with idiopathic thrombocytopenic purpura

J Thromb Thrombolysis. 2010 Aug;30(2):229-32. doi: 10.1007/s11239-009-0431-2.

Abstract

Recurrent cerebral infarctions developed in a patient with idiopathic thrombocytopenic purpura (ITP). At the time of the first stroke, there were large thrombi in the right proximal internal carotid artery (ICA) and an occlusion of the right terminal ICA. The occlusion was recanalized by intra-arterial infusion of urokinase. After 20 months, he suffered another ischemic attack. The autoantibodies in ITP directed against antigens presented on both platelets and endothelial cells might induce the endothelial damage, thrombus formation, and embolic occlusion of the artery.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticoagulants / administration & dosage
  • Autoantibodies / blood
  • Brain Ischemia / diagnosis
  • Brain Ischemia / drug therapy
  • Brain Ischemia / etiology*
  • Brain Ischemia / immunology
  • Cerebral Angiography
  • Diffusion Magnetic Resonance Imaging
  • Fibrinolytic Agents / administration & dosage
  • Heparin / administration & dosage
  • Humans
  • Intracranial Thrombosis / diagnosis
  • Intracranial Thrombosis / drug therapy
  • Intracranial Thrombosis / etiology*
  • Intracranial Thrombosis / immunology
  • Male
  • Purpura, Thrombocytopenic, Idiopathic / complications*
  • Purpura, Thrombocytopenic, Idiopathic / diagnosis
  • Purpura, Thrombocytopenic, Idiopathic / drug therapy
  • Purpura, Thrombocytopenic, Idiopathic / immunology
  • Recurrence
  • Stroke / diagnosis
  • Stroke / drug therapy
  • Stroke / etiology*
  • Stroke / immunology
  • Thrombolytic Therapy
  • Treatment Outcome
  • Urokinase-Type Plasminogen Activator / administration & dosage

Substances

  • Anticoagulants
  • Autoantibodies
  • Fibrinolytic Agents
  • Heparin
  • Urokinase-Type Plasminogen Activator