Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation

Org Lett. 2010 Jan 1;12(1):176-9. doi: 10.1021/ol9025815.

Abstract

A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations of various functionalized olefins such as alpha-arylenamides, alpha-(acylamino)acrylic acid derivatives, beta-(acylamino)acrylates, and dimethyl itaconate with excellent enantioselectivities (up to 99% ee) and reactivities (up to 2000 TON).

MeSH terms

  • Acrylates / chemistry*
  • Alkenes / chemistry
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Hydrogenation
  • Ligands
  • Molecular Structure
  • Organophosphorus Compounds / chemical synthesis*
  • Organophosphorus Compounds / chemistry
  • Rhodium / chemistry*
  • Stereoisomerism

Substances

  • Acrylates
  • Alkenes
  • Ligands
  • Organophosphorus Compounds
  • Rhodium