In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable electronics

Annu Int Conf IEEE Eng Med Biol Soc. 2009:2009:4880-3. doi: 10.1109/IEMBS.2009.5332457.

Abstract

An electronic device was fabricated consisting of 2 flexible electronic circuit islands, interconnected by a 7 cm long elastic interconnection, which could be elongated for at least 50%. This interconnection was based on gold conductor tracks following a 2-D spring pattern, embedded in a biocompatible silicone elastomer. The complete device was embedded in the same silicone elastomer. An in vitro cytotoxicity extraction test, executed on small test-samples in accordance with the ISO 10 993-1 guidelines, revealed that the applied silicone encapsulation to these samples functioned as a good seal for at least 8 days.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Cells, Cultured
  • Chickens
  • Electronics, Medical / instrumentation*
  • Electronics, Medical / methods*
  • Prostheses and Implants / adverse effects*
  • Silicones / chemistry

Substances

  • Silicones