A configurable IC for wireless real-time in vivo monitoring of chemical and electrical neural activity

Annu Int Conf IEEE Eng Med Biol Soc. 2009:2009:4222-5. doi: 10.1109/IEMBS.2009.5333089.

Abstract

A 16-channel chip for wireless in vivo recording of chemical and electrical neural activity is described. The 7.83-mm2 IC is fabricated using a 0.5-microm CMOS process and incorporates a 71-microW, 3rd-order, configurable, DeltaSigma modulator per channel, achieving an input-referred noise of 4.69 microVrms in 4-kHz BW and 94.1 pArms in 5-kHz BW for electrical and fastscan voltammetric chemical neurosensing, respectively. Brain extracellular levels of dopamine elicited by electrical stimulation of the medial forebrain bundle have been recorded wirelessly on multiple channels using 300-V/s fast-scan cyclic voltammetry in the anesthetized rat.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Computer Communication Networks*
  • Electronics
  • Electrophysiology
  • Equipment Design
  • Male
  • Microelectrodes
  • Models, Neurological
  • Monitoring, Ambulatory / instrumentation*
  • Monitoring, Ambulatory / methods
  • Nerve Net
  • Rats
  • Telemetry / instrumentation*
  • Telemetry / methods
  • Time Factors
  • Transducers