Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range

Angew Chem Int Ed Engl. 2010;49(2):337-40. doi: 10.1002/anie.200905597.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Deoxynojirimycin
  • Bacteria / enzymology
  • Binding Sites / drug effects
  • Crystallography, X-Ray
  • Cyclitols / chemical synthesis*
  • Cyclitols / pharmacology*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Hydrogen-Ion Concentration
  • Kinetics
  • Structure-Activity Relationship
  • Thermodynamics
  • alpha-L-Fucosidase / antagonists & inhibitors*
  • alpha-L-Fucosidase / chemistry

Substances

  • Cyclitols
  • Enzyme Inhibitors
  • 1-Deoxynojirimycin
  • alpha-L-Fucosidase