Objective: To analyze the reason of tumor treatment-related premature ovarian failure, and to review the progress of ovarian functional reconstruction.
Methods: The literature about the effects of radiotherapy and chemotherapy on ovarian function and reconstruct ovarian function was reviewed, analysed and summarized.
Results: Radiotherapy and chemotherapy can both affect ovarian function. The ovarian function reconstruction included fresh ovarian transplantation and ovarian cryopreservation and transplantation. Frequent ovarian cryopreservation was procedure slow-freezing protocols and vitrification protocols. Some laboratory and animal models of ovarian function reconstruction have come to gratifying results.
Conclusion: Ovarian function reconstruction has a potential clinical value and provides a promising future.