Abstract
Specific antibody responses in the lower respiratory tract of human subjects to orally administered Salmonella typhi Ty21a are reported. These responses, predominantly of the immunoglobulin G class, were determined to be a transudate from serum. These results were supported by the similarity in responses to parenteral administration of heat-killed typhoid vaccine. Specific immunoglobulin A antibody was a poor contributor to the respiratory antibody response to either vaccine.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Antibodies, Bacterial / biosynthesis*
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Antibodies, Bacterial / immunology
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Bronchoalveolar Lavage Fluid / immunology
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Exudates and Transudates
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Female
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Humans
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Immunoglobulin A / biosynthesis
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Immunoglobulin A / immunology
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Immunoglobulin G / biosynthesis
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Immunoglobulin G / immunology
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Intestines / immunology
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Male
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Random Allocation
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Respiratory System / immunology*
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Saliva / immunology
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Salmonella typhi / immunology*
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Typhoid-Paratyphoid Vaccines / administration & dosage
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Typhoid-Paratyphoid Vaccines / immunology*
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Vaccines, Attenuated / administration & dosage
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Vaccines, Attenuated / immunology
Substances
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Antibodies, Bacterial
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Immunoglobulin A
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Immunoglobulin G
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Typhoid-Paratyphoid Vaccines
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Vaccines, Attenuated