Abstract
A new dimeric guaianolide (8) and a new glaucolide (3), a seco-guaiaretic acid (4), two guaianolides (6 and 7), and five known sesquiterpene lactones (1, 2, 5, 9, and 10) were isolated from the aerial part of Artemisia anomala. Their structures were determined on the basis of chemical and spectroscopic analysis. In addition, their cytotoxic activities against five human cancer cell lines and anti-COX-2 effects in vitro were evaluated.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Artemisia / chemistry*
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Cyclooxygenase 2 Inhibitors / chemistry
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Cyclooxygenase 2 Inhibitors / isolation & purification*
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Cyclooxygenase 2 Inhibitors / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Humans
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Inhibitory Concentration 50
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Cyclooxygenase 2 Inhibitors
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Drugs, Chinese Herbal
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Lactones
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Sesquiterpenes