Abstract
Histone methylation on lysine 4 of histone H3 (H3K4) is a hallmark of activity of the transcribed regions on eukaryotic chromatin. H3K4 can be mono-, di- and trimethylated by Set1/COMPASS. In this review, we will discuss recent findings regarding the role of the Y/F switch by the catalytic domain of Set1 in the regulation of H3K4 methylation by Set1/COMPASS.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Histone-Lysine N-Methyltransferase / chemistry
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Histone-Lysine N-Methyltransferase / genetics
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Histone-Lysine N-Methyltransferase / metabolism*
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Histones / genetics
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Histones / metabolism*
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Humans
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Lysine / metabolism*
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Methylation
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Models, Molecular
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Protein Conformation
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / chemistry
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism*
Substances
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Histones
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Saccharomyces cerevisiae Proteins
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Histone-Lysine N-Methyltransferase
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SET1 protein, S cerevisiae
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Lysine