Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum

Phytother Res. 2010 Jun;24(6):821-6. doi: 10.1002/ptr.3022.

Abstract

Ten steroidal alkaloids - cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Drug Screening Assays, Antitumor
  • Female
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Molecular Structure
  • Plant Extracts / pharmacology*
  • Platelet Aggregation Inhibitors / pharmacology*
  • Rabbits
  • Veratrum / chemistry*
  • Veratrum Alkaloids / isolation & purification
  • Veratrum Alkaloids / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • Veratrum Alkaloids