Abstract
Survival was assessed among patients with disseminated renal carcinoma from different prognostic groups as established by MSKCC protocol. Multivariate evaluation pointed to prognostic value of IL-6 (spontaneous and induced production), IL-8 (spontaneous and induced production),TNF-alpha (spontaneous production), IFN-gamma (induced production), TNK-cells (CD3+CD16+CD56+), and T-regulatory cells (CD4+CD25+Treg). It was demonstrated that additional criteria may be used to evaluate prognosis.
MeSH terms
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Adult
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Aged
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Antigens, CD / immunology
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Biomarkers / blood
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Biomarkers, Tumor / blood*
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Carcinoma, Renal Cell / drug therapy*
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Carcinoma, Renal Cell / immunology*
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Carcinoma, Renal Cell / secondary
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Female
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Humans
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Immunotherapy / methods*
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Interferon-gamma / blood
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Interleukin-6 / blood
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Interleukin-8 / blood
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Kidney Neoplasms / drug therapy*
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Kidney Neoplasms / immunology*
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Kidney Neoplasms / pathology
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Killer Cells, Natural / immunology
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Male
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Middle Aged
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Multivariate Analysis
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Predictive Value of Tests
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Prognosis
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Survival Analysis
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T-Lymphocytes, Regulatory / immunology
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Treatment Outcome
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Tumor Necrosis Factor-alpha / blood
Substances
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Antigens, CD
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Biomarkers
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Biomarkers, Tumor
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Interleukin-6
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Interleukin-8
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Tumor Necrosis Factor-alpha
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Interferon-gamma