Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease

S Nouira; I Arfa; I Kammoun; A Abid; H Ouragini; I Dorboz; W Ghazouani; S Ben Fadhel; M M Zorgati; S Ben Ammar; S Blousa-Chabchoub; S Kachboura; S Abdelhak

doi:10.1016/j.diabres.2009.11.009

Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease

Diabetes Res Clin Pract. 2010 Feb;87(2):e7-10. doi: 10.1016/j.diabres.2009.11.009. Epub 2009 Dec 22.

Authors

S Nouira¹, I Arfa, I Kammoun, A Abid, H Ouragini, I Dorboz, W Ghazouani, S Ben Fadhel, M M Zorgati, S Ben Ammar, S Blousa-Chabchoub, S Kachboura, S Abdelhak

Affiliation

¹ Institut Pasteur de Tunis, Tunisia.

PMID: 20022652
DOI: 10.1016/j.diabres.2009.11.009

Abstract

We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5'-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphisms (p.Ser20Ile) is likely associated with cardiac disease.

2009. Published by Elsevier Ireland Ltd.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5' Untranslated Regions / genetics
AMP-Activated Protein Kinases / genetics*
Age of Onset
Aged
Base Sequence
Cardiovascular Diseases / genetics*
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / genetics*
Diabetic Angiopathies / genetics*
Exons / genetics*
Genetic Variation*
Humans
Medical History Taking
Middle Aged
Molecular Sequence Data
Polymorphism, Single Nucleotide*
Reference Values
Sequence Alignment
Sequence Homology, Nucleic Acid
Tunisia

Substances

5' Untranslated Regions
PRKAG2 protein, human
AMP-Activated Protein Kinases