Abstract
Glycine sarcosine methyltransferase (Gsm) and sarcosine dimethylglycine methyltransferase (Sdm) catalyze glycine betaine synthesis from glycine. Disruption of the M. xanthus gsmA (MXAN 7068) or sdmA (MXAN 3190) gene, encoding Gsm or Sdm homologue proteins, respectively, generated mutants that exhibited a longer lag period of growth and delayed spore germination under osmostress.
MeSH terms
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Amino Acid Sequence
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Betaine / metabolism*
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Gene Knockout Techniques
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Glycine / metabolism*
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Glycine N-Methyltransferase
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Molecular Sequence Data
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Mutagenesis, Insertional
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Myxococcus xanthus / growth & development
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Myxococcus xanthus / metabolism
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Myxococcus xanthus / physiology*
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Osmotic Pressure*
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Sequence Alignment
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Spores, Bacterial / growth & development
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Spores, Bacterial / metabolism
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Spores, Bacterial / physiology*
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Stress, Physiological*
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Water-Electrolyte Balance*
Substances
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Betaine
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Glycine N-Methyltransferase
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Glycine