Abstract
A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-substrates under room temperature or mild conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry
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Aldehydes / chemistry
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Carboxylic Acids
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Catalysis
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Copper / chemistry*
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Esters
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Indoles / chemical synthesis
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Indoles / chemistry*
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Ketones / chemistry
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Ligands
Substances
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Acetates
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Aldehydes
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Carboxylic Acids
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Esters
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Indoles
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Ketones
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Ligands
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indole-2-carboxylic acid
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Copper
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cyanoacetic acid