Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma

Sophie L Corthals; Mojca Jongen-Lavrencic; Yvonne de Knegt; Justine K Peeters; H Berna Beverloo; Henk M Lokhorst; Pieter Sonneveld

doi:10.1016/j.leukres.2009.10.026

Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma

Leuk Res. 2010 May;34(5):677-81. doi: 10.1016/j.leukres.2009.10.026. Epub 2009 Dec 23.

Authors

Sophie L Corthals¹, Mojca Jongen-Lavrencic, Yvonne de Knegt, Justine K Peeters, H Berna Beverloo, Henk M Lokhorst, Pieter Sonneveld

Affiliation

¹ Department of Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.

PMID: 20031211
DOI: 10.1016/j.leukres.2009.10.026

Abstract

We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of expression patterns in MM patients, independent of the chromosome 13 status. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions.

MeSH terms

Chromosomes, Human, Pair 13 / genetics*
Gene Deletion
Gene Dosage
Gene Expression
Gene Expression Profiling*
Humans
In Situ Hybridization, Fluorescence
MicroRNAs / genetics*
Multiple Myeloma / genetics*
Reverse Transcriptase Polymerase Chain Reaction

Substances

MIRN16 microRNA, human
MicroRNAs