Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis

Chew-Yan Gan; Yun-Yee Low; Tadahiro Etoh; Masahiko Hayashi; Kanki Komiyama; Toh-Seok Kam

doi:10.1021/np900576b

Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis

J Nat Prod. 2009 Dec;72(12):2098-103. doi: 10.1021/np900576b.

Authors

Chew-Yan Gan¹, Yun-Yee Low, Tadahiro Etoh, Masahiko Hayashi, Kanki Komiyama, Toh-Seok Kam

Affiliation

¹ Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, Iwaki Meisei University, 5-5-1 Iino, Chuo-dai, Iwaki, Fukushima 970-8551, Japan.

PMID: 20035556
DOI: 10.1021/np900576b

Abstract

Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance, Multiple
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology
KB Cells
Malaysia
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
Plant Stems / chemistry
Stereoisomerism
Vincristine / pharmacology

Substances

Indole Alkaloids
eburnamaline
Vincristine