Many genomic-scale datasets in plants have been generated over the last few years. This substantial achievement has led to impressive progress, including some of the most detailed molecular maps in any multicellular organism. Networks and pathways have been reconstructed using transcriptome, genome-wide transcription factor binding, proteome and metabolome data, and subsequently used to infer functional interactions among genes, proteins, and metabolites. However, more sophisticated systems biology approaches are needed to integrate different omics datasets. Ultimately, the integration of diverse and massive datasets into coherent models will improve our understanding of the molecular networks that underlie biological processes.