The aim of this study is to investigate the safety and efficacy of neoadjuvant chemotherapy for patients with hepatic colorectal cancer metastases who underwent hepatic resection. Surgical complications and survival rates of the patients with/without neoadjuvant chemotherapy were analyzed. Neoadjuvant chemotherapy was not associated with sever surgical complications after hepatic resection. Postoperative survival rate of the patients with neoadjuvant chemotherapy was not superior to that of patients without neoadjuvant chemotherapy. Neoadjuvant chemotherapy for patients with hepatic colorectal cancer metastases who underwent hepatic resection is safe, but further studies are required to clarify its efficacy.