Cognitive factors and willingness to participate in an HIV vaccine trial among HIV-negative injection drug users

Vaccine. 2010 Feb 17;28(7):1663-7. doi: 10.1016/j.vaccine.2009.12.023. Epub 2009 Dec 29.

Abstract

This cross-sectional study involving a cohort of injection drug users (IDU) examined the relationship between cognitive factors (HIV treatment optimism, self-efficacy and knowledge of vaccine trial concepts) as well as risk factors for seroconversion, and willingness to participate (WTP) in a preventive phase 3 HIV vaccine trial. Willingness to participate overall was 56%. In a multivariate analysis, for a 20-unit increase in a 100-point composite scale, self-efficacy was positively related to WTP (adjusted odds ratio [AOR]=1.95, 95% CI=1.40-2.70). HIV treatment optimism and knowledge of vaccine trial concepts were unrelated to WTP. Aboriginal ethnicity (AOR=3.47, 95% CI=1.68-7.18) and a higher educational level (>or=high school) (AOR=1.96, 95% CI=1.07-3.59) were positively related to WTP. This study provides information on WTP for an HIV vaccine trial. Limitations and future directions are also discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Vaccines / administration & dosage*
  • Adult
  • British Columbia
  • Clinical Trials, Phase III as Topic*
  • Cross-Sectional Studies
  • Drug Users / psychology*
  • Educational Status
  • Female
  • HIV Infections / prevention & control*
  • HIV Infections / psychology
  • Humans
  • Indians, North American
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Patient Participation / psychology*

Substances

  • AIDS Vaccines