A non-surgical therapeutic approach is illustrated with a case report of a breast cancer. Percutaneous implantation of electrodes in a breast permitted electrochemical treatment of a clinically, radiologically and cytologically verified cancer. Electrophoresis was induced between two implanted electrodes for about 2 h. No complaints were reported and no complications were observed. Bi-annual mammographic follow up could not disclose palpable or mammographic evidence of tumour remnants 2 years later.