Abstract
Four new 7, 20-epoxy-ent-kauranoids, rubluanins A-D (1-4) and eleven known ones, were isolated from Isodon rubescens var. lushanensis, and their structures were elucidated by spectroscopic analysis. Compounds 2-14 were evaluated for their cytotoxicity in several human tumor cell lines (U937, Jurkat, HL-60, K562, SGC790, and HepG2). Among the compounds, lasiokaurin (13) showed significant cytotoxic activity of 0.62 microM (IC(50)) in U937 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / analysis*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacokinetics*
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Cell Survival / drug effects
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Diterpenes / analysis
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes, Kaurane / analysis*
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Diterpenes, Kaurane / isolation & purification
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Diterpenes, Kaurane / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Isodon / chemistry*
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Models, Molecular
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Molecular Structure
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Neoplasms / drug therapy
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Diterpenes, Kaurane
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lasiokaurin