Abstract
Voltage-dependent Ca(2+) channels have been divided into at least 5 types (L-, N-, T-, P-, and Q-type). L/N-type Ca(2+) channel blocker cilnidipine could reduce the size of cerebral infarction in the rat focal brain ischemia. L-type Ca(2+) channel blocker amlodipine reduced cerebral edema and inhibit neuronal cell death. N-type Ca(2+) channel blocker omega-conotoxin reduce the size of cerebral infarction and inhibit delayed neuronal cell death in hippocampal CA1 area. It is suggested that calcium antagonist has neuroprotective effect.
MeSH terms
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Amlodipine / pharmacology*
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Amlodipine / therapeutic use*
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Animals
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Brain Edema / drug therapy*
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Calcium Channel Blockers / pharmacology*
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Calcium Channel Blockers / therapeutic use*
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Calcium Channels, L-Type
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Calcium Channels, N-Type
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Cell Death / drug effects
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Cerebral Infarction / drug therapy*
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Dihydropyridines / pharmacology*
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Dihydropyridines / therapeutic use*
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Hippocampus / cytology
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Humans
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Neurons / pathology
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Neuroprotective Agents*
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Rats
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omega-Conotoxins / pharmacology*
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omega-Conotoxins / therapeutic use*
Substances
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Calcium Channel Blockers
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Calcium Channels, L-Type
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Calcium Channels, N-Type
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Dihydropyridines
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Neuroprotective Agents
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omega-Conotoxins
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Amlodipine
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cilnidipine