Abstract
The authors report the occurrence of apathy, indifference, inattention, and perseveration in an obsessive compulsive patient taking high doses of fluoxetine. These changes were associated with a decrease in cerebral blood flow in the frontal lobes and changes in neuropsychological tests generally associated with frontal lobe impairment. These clinical manifestations disappeared 4 weeks after discontinuation of fluoxetine.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Brain Diseases / chemically induced*
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Brain Diseases / diagnosis
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Brain Diseases / physiopathology
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Cerebrovascular Circulation / drug effects
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Fluoxetine / adverse effects*
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Frontal Lobe / blood supply
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Frontal Lobe / drug effects*
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Frontal Lobe / physiopathology
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Humans
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Male
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Neuropsychological Tests
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Obsessive-Compulsive Disorder / drug therapy*
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Obsessive-Compulsive Disorder / physiopathology
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Tomography, Emission-Computed, Single-Photon