Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-L-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

A H Liao; F I Chou; Y C Kuo; H W Chen; J J Kai; C W Chang; F D Chen; J J Hwang

doi:10.1016/j.apradiso.2009.12.033

Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-L-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

Appl Radiat Isot. 2010 Mar;68(3):422-6. doi: 10.1016/j.apradiso.2009.12.033. Epub 2009 Dec 23.

Authors

A H Liao¹, F I Chou, Y C Kuo, H W Chen, J J Kai, C W Chang, F D Chen, J J Hwang

Affiliation

¹ Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.

PMID: 20056428
DOI: 10.1016/j.apradiso.2009.12.033

Abstract

A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4h post PBAD-lipiodol injection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Boron Neutron Capture Therapy / methods*
Boronic Acids / chemical synthesis
Boronic Acids / pharmacokinetics*
Boronic Acids / pharmacology
Fluorine Radioisotopes / pharmacokinetics*
Fluorine Radioisotopes / pharmacology
Iodized Oil / chemical synthesis
Iodized Oil / pharmacokinetics*
Iodized Oil / pharmacology
Liver Neoplasms, Experimental / metabolism*
Liver Neoplasms, Experimental / radiotherapy
Magnetic Resonance Imaging
Male
Phenylalanine / analogs & derivatives*
Phenylalanine / chemical synthesis
Phenylalanine / pharmacokinetics
Phenylalanine / physiology
Rats
Rats, Inbred F344
Tissue Distribution

Substances

Boronic Acids
Fluorine Radioisotopes
Phenylalanine
Iodized Oil