Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Oral Oncol. 2010 Mar;46(3):154-7. doi: 10.1016/j.oraloncology.2009.11.005. Epub 2010 Jan 6.

Abstract

We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p=0.013), lymph node metastasis (p=0.001), tumor stage (p=0.031) and tumor recurrence (p=0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r=0.223, p=0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell* / blood supply
  • Carcinoma, Squamous Cell* / metabolism
  • Female
  • Humans
  • Immunohistochemistry
  • Inhibitor of Differentiation Protein 1 / metabolism*
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Mouth Neoplasms* / blood supply
  • Mouth Neoplasms* / metabolism
  • Neovascularization, Pathologic* / pathology
  • Prognosis
  • Risk Factors
  • Treatment Outcome
  • Tumor Burden
  • Vascular Endothelial Growth Factor A / metabolism*

Substances

  • ID1 protein, human
  • Inhibitor of Differentiation Protein 1
  • Vascular Endothelial Growth Factor A