A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome

P Brown; P D Thompson; J C Rothwell; B L Day; C D Marsden

doi:10.1002/mds.870060114

A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome

Mov Disord. 1991;6(1):73-5. doi: 10.1002/mds.870060114.

Authors

P Brown¹, P D Thompson, J C Rothwell, B L Day, C D Marsden

Affiliation

¹ MRC Human Movement and Balance Unit, Institute of Neurology, London, England.

PMID: 2005926
DOI: 10.1002/mds.870060114

Abstract

We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.

MeSH terms

Acetamides / therapeutic use*
Adult
Aged
Anticonvulsants*
Female
Humans
Male
Middle Aged
Monoamine Oxidase Inhibitors*
Muscle Rigidity / drug therapy*
Myoclonus / drug therapy*
Neurologic Examination
Spasm / drug therapy
Syndrome

Substances

Acetamides
Anticonvulsants
Monoamine Oxidase Inhibitors
milacemide