Two new guaiane-type sesquiterpenoids from the fruits of Daucus carota L

Hong-wei Fu; Lin Zhang; Tao Yi; Yu-lin Feng; Jing-kui Tian

doi:10.1016/j.fitote.2009.12.008

Two new guaiane-type sesquiterpenoids from the fruits of Daucus carota L

Fitoterapia. 2010 Jul;81(5):443-6. doi: 10.1016/j.fitote.2009.12.008. Epub 2010 Jan 11.

Authors

Hong-wei Fu¹, Lin Zhang, Tao Yi, Yu-lin Feng, Jing-kui Tian

Affiliation

¹ Department of Biomedical Engineering, Zhejiang University, The Key Laboratory of Biomedical Engineering of the Ministry of Education, Hangzhou, PR China.

PMID: 20060880
DOI: 10.1016/j.fitote.2009.12.008

Abstract

Two new guaiane-type sesquiterpenoids containing an interesting epoxy unit, daucuside (1) and daucusol (2) were isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation and they were also evaluated for the cytotoxic effects against two human gastric cancer cell lines BGC-823 and AGS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Daucus carota / chemistry*
Fruit
Humans
Molecular Structure
Plant Extracts / chemistry*
Sesquiterpenes, Guaiane / chemistry
Sesquiterpenes, Guaiane / isolation & purification*
Stomach Neoplasms

Substances

Plant Extracts
Sesquiterpenes, Guaiane
daucuside
daucusol