NRG1 and BDNF genes in schizophrenia: an association study in an Italian case-control sample

Psychiatry Res. 2010 Mar 30;176(1):82-4. doi: 10.1016/j.psychres.2009.03.017. Epub 2010 Jan 12.

Abstract

We tested for associations between five single nucleotide polymorphisms (SNPs) located in the area containing the Neuregulin 1 gene (NRG1) and three SNPs within the brain-derived neutrophic factor gene (BDNF) in an Italian sample consisting of 171 schizophrenia subjects and 349 controls. No association was found for any of the polymorphisms tested, either in single locus or in haplotype analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain-Derived Neurotrophic Factor / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study / methods
  • Genotype
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Neuregulin-1 / genetics*
  • Polymorphism, Genetic / genetics*
  • Schizophrenia / genetics*

Substances

  • Brain-Derived Neurotrophic Factor
  • Neuregulin-1