Omega-3 polyunsaturated fatty acids affect sirolimus exposure in kidney transplant recipients on calcineurin inhibitor-free regimen

Transplantation. 2010 Jan 15;89(1):126-7. doi: 10.1097/TP.0b013e3181c280df.
No abstract available

Publication types

  • Letter

MeSH terms

  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 CYP3A Inhibitors
  • Drug Therapy, Combination
  • Fatty Acids, Omega-3 / therapeutic use*
  • Fatty Acids, Unsaturated / therapeutic use*
  • Humans
  • Hypertriglyceridemia / chemically induced
  • Hypertriglyceridemia / prevention & control*
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / pharmacokinetics
  • Immunosuppressive Agents / therapeutic use
  • Protein Kinases / adverse effects
  • Retrospective Studies
  • Sirolimus / adverse effects
  • Sirolimus / pharmacokinetics
  • Sirolimus / therapeutic use*
  • TOR Serine-Threonine Kinases

Substances

  • Cytochrome P-450 CYP3A Inhibitors
  • Fatty Acids, Omega-3
  • Fatty Acids, Unsaturated
  • Immunosuppressive Agents
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Sirolimus