BCR-ABL1 tyrosine kinase activity at diagnosis, as determined via the pCrkL/CrkL ratio, is predictive of clinical outcome in chronic myeloid leukaemia

Br J Haematol. 2010 May;149(3):458-60. doi: 10.1111/j.1365-2141.2009.08066.x. Epub 2010 Jan 11.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adaptor Proteins, Signal Transducing / blood*
  • Adult
  • Aged
  • Antineoplastic Agents / therapeutic use
  • Benzamides
  • Biomarkers, Tumor / blood*
  • Female
  • Humans
  • Imatinib Mesylate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis*
  • Male
  • Middle Aged
  • Neoplasm Proteins / blood
  • Nuclear Proteins / blood*
  • Piperazines / therapeutic use
  • Prognosis
  • Prospective Studies
  • Pyrimidines / therapeutic use
  • Treatment Outcome
  • Young Adult

Substances

  • Adaptor Proteins, Signal Transducing
  • Antineoplastic Agents
  • Benzamides
  • Biomarkers, Tumor
  • CRKL protein
  • Neoplasm Proteins
  • Nuclear Proteins
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate